Table 4.

Causal mediation analysis to evaluate the mediative effect of prevalent comorbidities on the association between gestational diabetes and long-term cardiovascular outcomes

	Proportion of mediated effect by diabetes	Proportion of mediated effect by hypertension	Proportion of mediated effect by dyslipidemia
Total cardiovascular outcome	0.21 (0.14–0.36)	0.11 (0.08–0.17)	0.10 (0.07–0.16)
ASCVD	0.30 (0.21–0.49)	0.12 (0.09–0.19)	0.14 (0.10–0.20)
Coronary artery disease	0.34 (0.23–0.63)	0.15 (0.10–0.25)	0.18 (0.13–0.31)
Myocardial infarction	0.26 (0.18–0.47)	0.09 (0.06–0.16)	0.10 (0.07–0.16)
Ischemic stroke	0.23 (0.14–0.55)	0.08 (0.05–0.19)	0.08 (0.05–0.21)
Peripheral artery disease	0.31 (0.20–0.75)	0.11 (0.08–0.30)	0.11 (0.07–0.24)
Non-ASCVD	0.19 (0.12–0.40)	0.11 (0.07–0.22)	0.08 (0.05–0.16)
Heart failure	0.35 (0.24–0.83)	0.12 (0.08–0.30)	0.12 (0.08–0.30)
Mitral regurgitation	0.06 (-0.04–0.18)	0.06 (0.04–0.12)	0.05 (0.02–0.12)
Atrial fibrillation/flutter	0.13 (0.07–0.32)	0.12 (0.08–0.26)	0.08 (0.04–0.16)

ASCVD atherosclerotic cardiovascular disease, non-ASCVD non-atherosclerotic cardiovascular disease