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. 2022 Sep 22;269(12):6310–6329. doi: 10.1007/s00415-022-11338-x

Table 3.

Main data of the included studies

Study Study design Experimental conditions Sample (N) Stimulation site Intensity and duration of tDCS Number of sessions Assessment measures Reported results Improvement in line bisection Improvement in cancelation task
Turgut et al. [68]

Parallel

No randomization

No blinding

-Dual tDCS + Optokinetic intervention + Conventional treatment

-Conventional treatment alone

32 PPC

1.5–2.0 mA

20 min

8 sessions

- Barthel Index

- Body orientation on the wheelchair

- Eye, head and trunk orientation (with and without cueing)

- Fim/IVAR Early Rehabilitation

- Line Bisection Test

- The Apples Cancellation Task

- The Clock Drawing Test

Combination intervention (dual tDCS + optokinetic + conventional treatment) reduces neglect for ipsilesional spontaneous body orientation and improves performance on the Clock Drawing Test compared to standard treatment No No
Bornheim et al. [11]

Crossover within-subjects

Case Reports Randomized

Double blinding

-a-tDCS + Physical therapy + Occupational therapy + Neuropsychological therapy

-Sham tDCS + Physical therapy + Occupational therapy + Neuropsychological therapy

4 M1

2 mA

20 min

20 sessions

- Catherine Bergego Scale

- Line Bisection Test

- The Star Cancellation Test

Active tDCS improves performance in the four patients in Catherine Bergego Scale, Line Bisection Test, and The Star Cancellation Test, expressed in percentage of change, compared to sham Yes Yes
O'Shea et al. [57]

Crossover within-subjects

3 cases study Longitudinal

Randomized

No blinding

-a-tDCS + Prism adaptation

-c-tDCS + Prism adaptation

-Sham tDCS + Prism adaptation

3 M1

1 mA

20 min

P1: 3 active and 5 sham sessions

P 2: 1 active and 1 sham sessions

-Balloons tests

-Coloring, reading and filling in a mock administrative form

-Copy Drawing

-Letter Cancellation, star cancellation test, object cancellation (dense and sparse search array)

-Line Bisection Test

-Ota test

-The Bells test

-Percent correct scores across the tests were combined to compute the overall neglect score for each patient (6 tests for P1; 10 tests for P2 and 3)

Improvement in neglect score after M1 tDCS + prism adaptation compared to sham

The improvement in neglect score lasted throughout follow-up (18–46 days)

Yes Yes
Yi et al. [74]

Parallel

Randomized

No blinding

-a-tDCS + Conventional physical therapy

-c-tDCS + Conventional physical therapy

-Sham tDCS + Conventional physical therapy

30 PPC

2 mA

30 min

15 sessions

- Catherine Bergego Scale

- Functional Ambulation Classification (basic motor skills)

- K-MMSE

- Korean Modified Barthel Index

- Line Bisection Test

- Motor-Free Visual Perception Test

- The Star Cancellation Test

Improvement in motor-free visual perception test, line bisection, star cancellation, Catherine Bergego Scale, Barthel Index, and Functional Ambulation Classification in all 3 groups (a-tDCS, c-tDCS, sham)

Improvements in the motor-free visual perception test, start cancellation, and line bisection were greater in a-tDCS and c-tDCS compared to sham

Yes Yes
Bang and Bong [5]

Parallel

Randomized

No blinding

-tDCS + Feedback training

-Feedback training alone

12 PPC

1 mA

20 min

15 sessions

- Barthel index

- Line Bisection Test

- Motor-Free Visual Perception Test

Improvement in Barthel index, line bisection test and motor-free visual perception test in the two groups

Combined tDCS + feedback intervention show greater improvement compared to feedback training alone in all tests

Yes Not assessed
Smit et al. [64]

Crossover within-subjects

No randomized

Double blinding

-Dual tDCS

-Sham dual tDCS

5 PPC

2 mA

20 min

5 sessions

Behavioral Inattention Test (BIT-C):

- Figure and Shape Copying

- Letter Cancellation

- Line Bisection Test

- Line Crossing

- Representational Drawing

- The Star Cancellation Test

No tDCS-related effects were observed for the BIT subtests No No
Làdavas et al. [47]

Parallel

Randomized

Double blinding

-a-tDCS + Prism adaptation

-c-tDCS + Prism adaptation

-Sham tDCS + Prism adaptation

30 PPC

2 mA

20 min

10 sessions

Behavioral Inattention Test (BIT-C):

- Figure and Shape Copying

- Letter Cancellation

- Line Bisection Test

- Line Crossing

- Representational Drawing

- The Star Cancellation Test

a-tDCS PPC boosted neglect amelioration after prism adaptation

c-tDCS suppresses neglect improvement after prism adaptation

Yes Yes
Brem et al. [12]

Crossover within-subjects

No randomized

Double blinding

-Dual tDCS + Conventional cognitive therapy

-Sham tDCS + conventional cognitive therapy

1 PPC

1 mA

20 min

6 sessions

Test for Attentional Performance:

- Alertness

- Covert Attention

- Visual field From Neglect-Test

German version of BIT:

- Cancellation

- Copying figures

- Line Bisection Test

Transfer effects on ADL

Combined intervention (dual tDCS + cognitive therapy) showed greater improvement compared to sham in cover attention, line bisection, and coping

ADLs showed improvement at the 3 month follow-up

Yes No
Sunwoo et al. [67]

Crossover within-subject

Randomized

Double blinding

-Dual tDCS

-a-tDCS

-Sham tDCS

10 PPC

1 mA

20 min

3 days

Dual tDCS (1)

a-tDCS (1)

- Line Bisection Test

- The Star Cancellation Test

Significant improvements in line bisection after both dual and single tDCS, but not after sham, being stronger the effect after dual tDCS

No significant change in star cancellation

Yes No
Sparing et al. [66]

Crossover within-subjects

No randomized

No blinding

-a-tDCS contralesional PPC

-c-tDCS contralesional PPC

-a-tDCS lesioned PPC

-Sham tDCS lesioned PPC

10 PPC

1 mA

10 min

2 days

- Line Bisection Test (computerized version)

- Neglect subtest of Test Battery of Attentional Performance’ (TAP)

Both a-tDCS (ipsilesional) and c-tDCS (contralesional) improved line bisection compared to sham

No significant changes were detected in neglect subtest of TAP (only a tendency of contralesional c-tDCS)

Yes Not assessed
Ko et al. [46]

Crossover within-subjects

No randomized

Double blinding

-a-tDCS

-Sham tDCS

15 PPC

2 mA

20 min

2 sessions

- Letter-Structured Cancellation Test

- Line Bisection Test

- Shape-Unstructured Cancellation Test

a-tDCS showed significant improvement in cancellation tests and line bisection tests compared to sham Yes Yes