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. 2022 Jul 23;269(12):6366–6376. doi: 10.1007/s00415-022-11256-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Flow chart of patients included in the study. During the study period, 38 pediatric MOGAD or MS patients after the first ON attack were identified in the participating centers. Four patients were excluded due to second ON attack during the first 6 months after the initial event. Depending on the diagnosis, the pediatric patients were divided into 2 groups: group (1) 13 MOG-IgG-patients with initial manifestation < 18 years (MOGAD^paed) and group (2) 21 MS patients with initial manifestation < 18 years (MS^ped)