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. 2022 Oct 17;9:997992. doi: 10.3389/fmed.2022.997992

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Copyright © 2022 Wolfertz, Böhm, Keitel, Hannappel, Kümpers, Bernhard and Michael.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prisma chart. A total of 6,607 patients were detected from the patient management system database as a potential study population. These 6,607 patients were screened for inclusion and exclusion criteria, resulting in the inclusion of 1,278 patients with documented infection focus. A total of 5,329 patients had to be excluded from the study because of relevant exclusion criteria (e.g., age < 18 years. Incomplete records, no infection focus). The study population of 1,278 patients was divided into infection (group I), sepsis (group II), and septic shock (group III) groups.