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. 2022 Oct 17;9:922790. doi: 10.3389/fcvm.2022.922790

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Copyright © 2022 He, Li, Feng, Gao, Li, Chu, Li, Wang, Mao, Ji, Hua, Shen, Wang, Zhao and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The protective effect of human-induced pluripotent stem cell- endothelial cell-extracellular vesicle (hiPSC-EC-EV) on carotid artery through inhibition of EC apoptosis. (A–D) Representative immunostaining images stained for CD31 (Red) and Ki67 (Green) in panel (A), stained for CD31 (Red) and TUNEL (Green) in panel (B), stained for α-SMA (Red) and Ki67 (Green) in panel (C), and stained for α-SMA (Red) and TUNEL (Green) in panel (D) in the carotid arteries 21 days after the surgery. Data represent mean ± SD from three independent experiments (n = 3). Differences between linked groups were evaluated by two-tailed Student’s t-test. *p < 0.05 vs. Sham; ^#p < 0.05 vs. PBS.