Table 1.

Main characteristics of studies included in this meta-analysis.

SNP	First Author	Ethnicity	Sample size		Cases					Controls					HWE P value	Source of control	Genotyping method
			Case	Control	genotypes			allele		genotypes			allele
rs2435357					TT	CT	CC	T	C	TT	CT	CC	T	C
	Zhang 2007	Asian	99	132	57	28	14	142	56	29	62	41	120	144	0.544	H-B	PCR
	Arnold 2008	Europe	62	30	12	27	23	51	70	2	14	14	18	42	0.542	H-B	TaqMan
	Miao 2010	Asian	315	352	228	65	22	521	109	62	169	95	293	359	0.39	H-B	PCR
	Phusantisampan 2012	Asian	68	120	47	14	7	108	28	31	64	25	126	114	0.447	H-B	PCR-RFLP
	Prato 2009	Europe	22	85	11	6	5	28	16	3	32	50	38	132	0.435	H-B	PCR
	Zhang 2015	Asian	135	118	101	31	3	233	37	13	30	16	56	62	0.88	NS	TaqMan
	Gunadi 2016	Asian	93	136	67	22	4	156	30	27	83	26	137	135	0.01	NS	PCR-RFLP
	Yang 2017	Asian	362	1448	209	126	27	544	180	329	802	317	1460	1436	0.001	P-B	TaqMan
	Li 2017	Asian	99	114	69	27	3	165	33	19	58	37	96	132	0.641	NS	TaqMan
	Qian Jiang 2021	Asian	120	509	88	30	2	206	34	100	252	157	452	566	0.44	H-B	Sequenom
	Yang Wang 2020	Asian	491	509	320	146	25	786	196	100	252	157	452	566	yes	H-B	Sequenom
	Kristy Iskandar 2022	Asian	73	60	62	11	0	135	11	20	34	6	74	46	yes	H-B	TaqMan
rs2506030					AA	AG	GG	A	G	AA	AG	GG	A	G
	Gunadi 2019	Asian	60	122	3	21	36	27	93	15	50	57	80	164	yes	H-B	TaqMan
	Qian Jiang 2021	Asian	120	512	3	32	85	38	202	42	205	265	289	735	0.44	H-B	Sequenom
	DehuaYang 2017	Asian	345	1148	13	111	221	137	553	143	550	755	836	2060	yes	H-B	TaqMan
	Yang Wang 2020	Asian	502	513	15	137	346	167	829	42	205	265	289	735	yes	H-B	Sequenom
	Qian Jiang 2015	Epure	586	586	109	272	205	490	682	207	273	106	687	485	yes	NS	TaqMan
	Qi Li 2017	Asian	99	114	2	20	77	24	174	11	46	57	68	160	yes	NS	TaqMan
	Zhen Zhang 2015	Asian	137	59	3	26	108	32	242	5	22	32	32	86	yes	NS	Taqman

PCR, polymerase chain reaction restriction; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; H-B, hospital-based; P-B, population-based; NS, not stated; HWE, Hardy–Weinberg equilibrium.