Table 3.

Analysis results of the association between rs2435357 and HSCR risk.

Subgroup	Genetic Model	Type of Model	Heterogeneity		Odds Ratio
			I2 (%)	PH	OR	95% CI	Ztest	POR
Overall
	T vs. C	Random	0.798	0.000	4.743	[3.720; 6.047]	12.555	3.72E–36
	TC vs. CC	Random	0.678	0.000	15.188	[9.167; 25.165]	10.560	4.55E–26
	TT vs. CC	Random	0.496	0.026	2.272	[1.828; 2.824]	4.187	2.82E–05
	TT + TC vs. CC	Random	0.787	0.000	6.521	[3.533; 12.037]	5.996	2.02E–09
	TT vs. TC + CC	Random	0.760	0.000	9.049	[6.694; 12.231]	14.325	1.52E–46
Source of controls
HB
	T vs. C	Random	0.732	0.000	4.617	[3.346; 6.370]	9.310	1.23E–20
	CT vs. CC	Random	0.665	0.004	13.842	[7.167; 26.732]	7.830	5.07E–15
	TT vs. CC	Random	0.587	0.018	1.946	[1.194; 3.171]	2.670	7.59E–03
	TT + CT vs. CC	Random	0.729	0.001	4.897	[2.682; 8.943]	5.170	2.33E–07
	TT vs. CT + CC	Random	0.515	0.044	8.707	[6.527; 11.615]	14.720	4.80E–49
others
	T vs. C	Random	0.854	0.000	4.988	[3.241; 7.678]	7.300	2.80E–13
	CT vs. CC	Random	0.746	0.008	18.722	[7.453; 47.033]	6.230	4.55E–10
	TT vs. CC	Random	0.381	0.183	2.265	[1.565; 3.279]	4.330	2.02E–03
	TT + CT vs. CC	Random	0.884	0.000	11.351	[2.933; 43.939]	3.520	4.35E–04
	TT vs. CT + CC	Random	0.885	0.000	10.218	[5.140; 20.313]	6.630	3.36E–11
Genotyping methods
TaqMan
	T vs. C	Random	0.856	0.000	4.475	[2.563; 7.812]	5.271	1.36E–07
	CT vs. CC	Random	0.704	0.009	16.094	[5.666; 45.714]	5.216	1.83E–07
	TT vs. CC	Fixed	0.388	0.162	2.161	[1.518; 3.077]	4.270	6.64E–03
	TT + CT vs. CC	Random	0.881	0.000	9.096	[2.142; 38.630]	2.992	2.77E–03
	TT vs. CT + CC	Random	0.846	0.000	9.193	[4.724; 17.892]	6.530	6.59E–11
Others
	T vs. C	Random	0.534	0.092	5.205	[3.965; 6.831]	11.889	1.35E–32
	CT vs. CC	Random	0.692	0.021	17.283	[6.924; 43.136]	6.106	1.02E–09
	TT vs. CC	Random	0.716	0.014	2.499	[0.972; 6.426]	1.900	5.74E–02
	TT + CT vs. CC	Random	0.705	0.017	6.639	[2.750; 16.027]	4.210	2.56E–05
	TT vs. CT + CC	Fixed	0.014	0.385	8.534	[6.768; 10.762]	18.120	2.23E–73