Table 4.

Analysis results of the association between rs2506030 and HSCR risk.

Subgroup	Genetic Model	Type of Model	Heterogeneity		Odds Ratio
			I2 (%)	PH	OR	95% CI	Ztest	POR
Overall
	A vs. G	Fixed	0.255	0.234	0.519	[0.469; 0.573]	−12.039	2.21E–33
	AG vs. GG	Fixed	0.000	0.962	0.270	[0.211; 0.346]	−10.561	4.53E–26
	AA vs. GG	Fixed	0.298	0.200	0.543	[0.474; 0.623]	−7.179	7.00E–13
	AA + AG vs. GG	Fixed	0.000	0.541	0.410	[0.360; 0.468]	−13.295	2.49E–40
	AA vs. AG + GG	Fixed	0.000	0.803	0.361	[0.292; 0.447]	−8.338	7.54E–17
Source of controls
Others
	A vs. G	Fixed	0.475	0.149	0.475	[0.408; 0.552]	−5.390	7.06E–08
	AG vs. GG	Fixed	0.000	0.599	0.258	[0.188; 0.353]	−8.390	4.81E–17
	AA vs. GG	Fixed	0.179	0.296	0.458	[0.358; 0.585]	−4.920	8.84E–07
	AA + AG vs. GG	Fixed	0.000	0.483	0.377	[0.300; 0.475]	−8.290	1.13E–16
	AA vs. AG + GG	Fixed	0.000	0.490	0.400	[0.308; 0.518]	−6.200	5.75E–10
HB
	A vs. G	Fixed	0.000	0.561	0.553	[0.484; 0.632]	−8.770	1.83E–18
	AG vs. GG	Fixed	0.000	0.962	0.286	[0.195; 0.420]	−6.420	1.33E–10
	AA vs. GG	Fixed	0.109	0.338	0.586	[0.497; 0.692]	−5.210	1.93E–07
	AA + AG vs. GG	Fixed	0.000	0.422	0.427	[0.364; 0.501]	−9.570	1.02E–21
	AA vs. AG + GG	Fixed	0.000	0.943	0.306	[0.210; 0.446]	−6.080	1.20E–09
Genotyping methods
TaqMan
	A vs. G	Fixed	0.490	0.098	0.525	[0.467; 0.591]	−6.610	3.92E–11
	AG vs. GG	Fixed	0.000	0.851	0.274	[0.208; 0.361]	−9.400	5.68E–21
	AA vs. GG	Fixed	0.496	0.094	0.565	[0.477; 0.670]	−4.540	5.51E–06
	AA + AG vs. GG	Fixed	0.000	0.507	0.385	[0.327; 0.453]	−11.450	2.36E–30
	AA vs. AG + GG	Fixed	0.000	0.593	0.368	[0.292; 0.465]	−6.350	2.16E–10
Others
	A vs. G	Fixed	0.000	0.755	0.504	[0.418; 0.607]	−7.220	5.04E–13
	AG vs. GG	Fixed	0.000	0.764	0.262	[0.152; 0.452]	−4.820	1.41E–06
	AA vs. GG	Fixed	0.000	0.849	0.505	[0.401; 0.636]	−5.810	6.08E–09
	AA + AG vs. GG	Fixed	0.000	0.824	0.461	[0.370; 0.575]	−6.880	6.09E–12
	AA vs. AG + GG	Fixed	0.000	0.785	0.333	[0.194; 0.569]	−4.010	6.00E–05