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. 2022 Oct 12;25(11):105334. doi: 10.1016/j.isci.2022.105334

Figure 2.

Figure 2

Metabolomic signatures associated with LDLR functional status

(A) VIP plots of each metabolite variation in pairwise comparisons of defective/defective, null/defective, and null/null groups; the dashed lines indicate the threshold for the significant differences.

(B) Hierarchical clustering heatmap of LDLR status-associated metabolite intensities in different groups.

(C) PCA scores plot of the differentiated metabolites; each point represents an individual sample. CE = cholesterol esters, TAG = triacylglycerides, LysoPC = lysophosphocholines, LysoPC O = alkyl LysoPC, LysoPE O = alkyl lysophosphoethanolamines, LysoPA = lysophosphatidic acid, LPI = lysophosphatidylinositol.