TABLE 1.
Properties | Parameters |
---|---|
MW | 302.24 g/mol |
hydrogen bond donor | 5 |
hydrogen bond acceptors | 7 |
lipophilicity (logP) | 0.524260 |
XLogP3 | 1.53 |
No. Rotatable bonds | 9 |
Molar refractivity | 64.369995 |
TPSA | 131.36 Å |
GIT absorption | 77.207% |
Level of BBB | −1.098 (log BB) |
MW, Molecular weight; TPSA, Topological polar surface area; BBB, blood brain barrier; GIT, gastrointestinal; XLogP3, water partition coefficient/computed octanol.