TABLE 2.
Analysis of Quercetin targets with the phenotype “Essential hypertension” using VarElect.
| S.No | Description | Gene symbols | Score | Phenotypic correlations |
|---|---|---|---|---|
| 1 | Gap Junction Protein Alpha 1 | GJA1 | 31.76 | Directly |
| 2 | Caveolin 1 | CAV1 | 31.41 | Directly |
| 3 | Peroxisome Proliferator Activated Receptor Gamma | PPARG | 30.41 | Directly |
| 4 | Fos Proto-Oncogene, AP-1 Transcription Factor Subunit | FOS | 25.46 | Directly |
| 5 | Collagen Type III Alpha 1 Chain | COL3A1 | 23.69 | Directly |
| 6 | Raf-1 Proto-Oncogene, Serine/Threonine Kinase | RAF1 | 23.57 | Directly |
| 7 | Cyclin D1 | CCND1 | 18.43 | Directly |
| 8 | Phosphatase And Tensin Homolog | PTEN | 16.30 | Directly |
| 9 | Transforming Growth Factor Beta 1 | TGFB1 | 16.19 | Directly |
| 10 | Bone Morphogenetic Protein 2 | BMP2 | 15.66 | Directly |
| 11 | Interleukin 10 | IL10 | 14.73 | Directly |
| 12 | Matrix Metallopeptidase 1 | MMP1 | 11.78 | Directly |
| 13 | Adrenoceptor Beta 2 | ADRB2 | 11.36 | Directly |
| 14 | Nitric Oxide Synthase 3 | NOS3 | 10.52 | Directly |
| 15 | Insulin Like Growth Factor 2 | IGF2 | 9.59 | Directly |
| 16 | Tumor Protein P53 | TP53 | 6.29 | Directly |
| 17 | Thrombomodulin | THBD | 6.29 | Directly |
| 18 | Heme Oxygenase 1 | HMOX1 | 4.47 | Directly |
| 19 | Mitogen-Activated Protein Kinase 1 | MAPK1 | 3.44 | Directly |
| 20 | Secreted Phosphoprotein 1 | SPP1 | 2.43 | Directly |
| 21 | Interleukin 6 | IL6 | 2.43 | Directly |
| 22 | Cyclin Dependent Kinase Inhibitor 2A | CDKN2A | 1.62 | Directly |
| 23 | Interleukin 1 Beta | IL1B | 1.42 | Directly |
| 24 | Interleukin 1 Alpha | IL1A | 1.42 | Directly |
| 25 | SMAD Family Member 4 | SMAD4 | 19.26 | Indirectly |
| 26 | KRAS Proto-Oncogene, GTPase | KRAS | 19.26 | Indirectly |
| 27 | Signal Transducer and Activator of Transcription 1 | STAT1 | 19.26 | Indirectly |
| 28 | TNF Superfamily Member 11 | TNFSF11 | 13.54 | Indirectly |
| 29 | Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma | IKBKG | 13.54 | Indirectly |
| 30 | Major Histocompatibility Complex, Class I, B | HLA-B | 13.54 | Indirectly |
| 31 | Major Histocompatibility Complex, Class II, DR Beta 1 | HLA-DRB1 | 13.54 | Indirectly |
| 32 | Fibroblast Growth Factor Receptor 1 | FGFR1 | 9.42 | Indirectly |
| 33 | SOS Ras/Rac Guanine Nucleotide Exchange Factor 1 | SOS1 | 9.42 | Indirectly |
| 34 | Janus Kinase 2 | JAK2 | 9.32 | Indirectly |
| 35 | Notch Receptor 1 | NOTCH1 | 7.99 | Indirectly |
| 36 | Von Hippel-Lindau Tumor Suppressor | VHL | 7.99 | Indirectly |
| 37 | E1A Binding Protein P300 | EP300 | 7.99 | Indirectly |
| 38 | C-C Motif Chemokine Receptor 6 | CCR6 | 7.92 | Indirectly |
| 39 | Signal Transducer and Activator of Transcription 3 | STAT3 | 7.92 | Indirectly |
| 40 | Bone Morphogenetic Protein Receptor Type 2 | BMPR2 | 7.55 | Indirectly |
| 41 | Interleukin 12B | IL12B | 7.06 | Indirectly |
| 42 | Filamin A | FLNA | 6.52 | Indirectly |
| 43 | Proteinase 3 | PRTN3 | 6.52 | Indirectly |
| 44 | Transforming Growth Factor Beta Receptor 1 | TGFBR1 | 6.52 | Indirectly |
| 45 | AKT Serine/Threonine Kinase 1 | AKT1 | 6.08 | Indirectly |
| 46 | Interleukin 12A | IL12A | 5.70 | Indirectly |
| 47 | Transforming Growth Factor Beta Receptor 2 | TGFBR2 | 5.63 | Indirectly |
| 48 | Cytochrome P450 Family 1 Subfamily A Member 1 | CYP1A1 | 3.87 | Indirectly |
| 49 | Catechol-O-Methyltransferase | COMT | 3.87 | Indirectly |
| 50 | B-Raf Proto-Oncogene, Serine/Threonine Kinase | BRAF | 5.63 | Indirectly |
| 51 | WT1 Transcription Factor | WT1 | 2.85 | Indirectly |
| 52 | FMRP Translational Regulator 1 | FMR1 | 2.85 | Indirectly |
| 53 | Solute Carrier Family 2 Member 10 | SLC2A10 | 1.32 | Indirectly |
| 54 | Collagen Type I Alpha 2 Chain | COL1A2 | 1.32 | Indirectly |