TABLE 2.
Overview of mini pig species used for transgenic pig models.
| Species | Species of origin | Application/target gene | Year | Technique | Reference |
|---|---|---|---|---|---|
| Yucatan miniature pig | One breed of native wild pigs in Península de Yucatán of Mexico | Creating male and female LDLR+/−pigs | 2014 | Adeno-associated virus-mediated gene targeting | Wells and Prather, (2017) |
| SCNT | |||||
| GGTA1-knockout Yucatan miniature pigs | 2020 | TALEN | Pan et al. (2019) | ||
| Nuclear transfer | |||||
| GGTA1 | 2021 | Triple knockout of genes | Li et al. (2015) | ||
| Cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) | |||||
| Alpha 1,3-galactosyltransferase 2 (A3GALT2) | |||||
| Gottingen minipig | Crossing German Landrace, Vietnamese potbelly swine | Double-transgenic Gottingen minipig model for Alzheimer’s disease | 2016 | SCNT | Shim et al. (2021) |
| WZS pig | One breed of Hainan province | Models with GH functions in relation to cancer, diabetes, and longevity | 2015 | Handmade cloning with impaired systemic GHR activity | Panepinto and Phillips, (1986) |
| Bama minipig | One breed of Guangxi province | Providing assessment and establishment of producing pig transgenic models | 2015 | SCNT | Jakobsen et al. (2016) |