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Exosomal miRNA in situ detection using SERS biosensor combined with Fe3O4@TiO2-based concentration. SERS tags are adsorbed to exosomes and bind to the target exosomal miRNA (A). The hot spots and SERS intensity increase, and SERS intensity increases as Fe3O4@TiO2 captures exosome for in situ detection of exosomal miRNAs (B). Reprinted with permission from Jiang et al. (2021a).
