Table 2.
Results of GO and PANTHER pathway enrichment analyses in CHIP-positive individuals
| Source | Term name | Term ID | Gene (N) | Fold enrichment | Raw P | FDR |
|---|---|---|---|---|---|---|
| GO:CC | Specific granule lumen | GO:0035580 | 9 | 20.81 | 1.50E-09 | 3.06E-06 |
| GO:CC | Tertiary granule lumen | GO:1904724 | 7 | 17.95 | 2.64E-07 | 1.08E-04 |
| GO:CC | Specific granule | GO:0042581 | 10 | 8.87 | 3.38E-07 | 1.15E-04 |
| GO:CC | Secretory granule lumen | GO:0034774 | 14 | 6.17 | 1.07E-07 | 1.10E-04 |
| GO:CC | Cytoplasmic vesicle lumen | GO:0060205 | 14 | 6.11 | 1.07E-07 | 1.10E-04 |
| GO:CC | Tertiary granule | GO:0070820 | 9 | 7.74 | 3.86E-06 | 9.85E-04 |
| GO:CC | Vesicle lumen | GO:0031983 | 14 | 6.07 | 1.29E-07 | 6.57E-05 |
| GO:CC | Secretory vesicle | GO:0099503 | 23 | 3.11 | 1.57E-06 | 4.58E-04 |
| GO:CC | Secretory granule | GO:0030141 | 20 | 3.22 | 4.84E-06 | 1.10E-03 |
| Reactome | Neutrophil degranulation | R-HSA-6798695 | 17 | 5.03 | 7.66E-08 | 1.91E-04 |
| Reactome | Innate immune system | R-HSA-168249 | 23 | 2.93 | 4.17E-06 | 5.20E-03 |
Abbreviations: FDR, false discovery rate; GO, Gene Ontology; GO:CC, GO cellular component; CHIP, clonal hematopoiesis of indeterminate potential; PANTHER, Protein Analysis Through Evolutionary Relationships (http://www.pantherdb.org/).