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. 2022 Oct 17;13:930511. doi: 10.3389/fimmu.2022.930511

Figure 1.

Figure 1

Osteoarthritis (OA) leads to an imbalanced intestinal environment and an altered microbiome. (A) Intestinal epithelial tissue images of the healthy (WT) and diseased (monosodium iodoacetate, MIA) groups at 3 weeks after OA induction (magnification ×200). (B) Intestinal tight junction protein expression (magnification ×200). (C) Expression of inflammatory factors by immunohistochemistry (IHC) (magnification ×200). (D) The microbiome of fecal samples in WT and MIA. (E) The abundance of Lactobacillus in WT and MIA. Data are means ± SD (*p < 0.05, **p < 0.01, ****p < 0.001), ns, not significant.