Table 1b.

Diagnostic studies and evaluations for Patient # 2.

Infectious	Autoimmune/inflammatory	Metabolic
CSF and Blood cultures: negative HSV PCR CSF: negative CSF and Serum Arbovirus CSF EBV, VZV PCR: negative CSF RPR and VDRL (CSF) negative Bartonella serology and PCR: Negative Mycoplasma: Negative COVID Ag and Ab testing negative	CSF 12/30/20: 4 WBC, 49 protein, 71 glucose Autoimmune encephalopathy panel: negative (serum and CSF) Pelvic US: negative for teratoma CSF oligoclonal bands: negative NMO antibodies: negative ANA, dsDNA, ACE Lysozyme CSF cytokines showed no elevation and serum cytokines showed elevation of IL-6.	Vit. B12, TSH/FT4, folate, copper, ceruloplasmin: Normal Acylcarnitine profile: normal Urine organic acids: normal Plasma amino acids: normal Heavy metals: normal Porphyria: negative Very long chain fatty acids: normal

Imaging	Genetic
MRI Brain: Abnormal (*) Negative MRA/MRV of the head and neck	Epilepsy panel: negative Whole exome sequencing (TRIO): negative

^*MRI brain demonstrated FLAIR changes in bilateral temporal lobes consistent with prolonged seizures.