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. 2022 Oct 26;6(11):e794. doi: 10.1097/HS9.0000000000000794

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Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Figure 1. — Absolute numbers of lymphocytes and their subsets in the PB of limited-stage and advanced-stage cHL patients before primary treatment. Comparing healthy controls (n = 20) to limited-stage (n = 28) and advanced-stage (n = 20) cHL patients. (A) Absolute lymphocyte count (ALC) and absolute numbers of major lymphocyte populations (B cells, T cells, CD4⁺ T cells, CD8⁺ T cells, and CD4/CD8 ratio). (B) Absolute numbers of T helper cells (Th1 cells, Th2 cells, Th1/Th2 ratio, Th17 cells, and Tregs) and concentrations of CCL17/TARC in plasma. (C) Percentages of CD4⁺ T cells that are expressing functional markers (Ki67, CD69, PD-1, and CTLA-4) and absolute numbers of CD4⁺ TN and TEM cells. (D) Percentages of CD8⁺ T cells that are expressing functional markers (Ki67, CD69, PD-1, and CTLA-4) and absolute numbers of CD8⁺ TN and TEM cells. (E) Absolute numbers of NK cells, CD56^dim NK cells, CD56^bright NK cells, and percentages of NK cells that are expressing functional markers (CD69, HLA-DR, NKG2D, and DNAM-1). The CD4/CD8 ratio, Th1/Th2 ratio, and CCL17/TARC data are depicted as box and whiskers plots in the style of Tukey. All other data are depicted as violin plots with a thick line at the median and thin lines at the quartiles. Stars indicate the P-value of a Mann-Whitney test comparing the indicated groups. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. ADV = advanced-stage; cHL = classical Hodgkin lymphoma; CTLA = cytotoxic T lymphocyte antigen; DNAM = DNAX accessory molecule; LIM = limited-stage; NK = natural killer; NKG2D = NK group 2 member D; PB = peripheral blood.