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. 2022 Oct 17;12:1040736. doi: 10.3389/fonc.2022.1040736

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Copyright © 2022 Zhang, Ma, Zhou, Zhou, Liu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mutation analysis of the 8-gene signature. (A) Differential expression of the eight genes in TCGA HCC tissues and normal adjacent tissues. Red(log2FC>1) indicates high expression, while blue indicates low expression. (B) Homozygous copy number variation of the eight genes in the TCGA HCC cohort. Amplifications are shown on the left and deletions are shown on the right. (C) Heterozygous copy number variation of the eight genes in the TCGA HCC cohort. (D) Single nucleotide variant (SNV) variation of the eight genes in the TCGA HCC cohort. (E) Correlation analysis of the expression of the eight genes and drug sensitivity using the CTRP database.