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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: J Stroke Cerebrovasc Dis. 2022 Aug 27;31(10):106742. doi: 10.1016/j.jstrokecerebrovasdis.2022.106742

Fig. 2. X-ray crystal structure of milvexian bound to factor XIa (Protein Data Bank ID: 7MBO).

Fig. 2.

Milvexian is represented as a stick model (atom colors: C, orange; O, red; N, blue; Cl, green; F, light blue; H, not shown). The molecular surface of Factor XIa is displayed colored by electrostatic potential (blue: positive; red: negative; white: neutral). Amino acid labels are displayed for the catalytic triad residues (His57, Asp102, Ser195) and selected residues (Arg39, Asp189, Lys192, Tyr228) that are within a distance of 3.5 angstroms from milvexian. This illustration was created using the PyMOL Molecular Graphics System, version 1.7.6.0, Schrödinger, LLC, New York.