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. 2021 Mar 1;184(3):577–579. doi: 10.1111/bjd.19670

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© 2021 British Association of Dermatologists

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(a, b) ACE2 and TMPRSS2 transcript expression profiles in peripheral blood (a) and skin (b) of patients with psoriasis (n = 40) and healthy controls (n = 40 in blood, n = 30 in skin) (Mann–Whitney U‐test; mean and SEM). (c) Protein expression of angiotensin‐converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2) was determined in skin homogenates of patients with psoriasis (n = 40) and controls (n = 30) in triplicate (Student’s t‐test). (d) The effect of polyinosinic–polycytidylic acid [poly(I:C)] – alone or in combination with recombinant human interferon‐γ (rhIFN‐γ) – on ACE2 and TMPRSS2 expression. Left: immunofluorescence staining (original magnification × 40); right: transcript quantification (in triplicate) in adult human epidermal keratinocytes for 24 h (one‐way anova test). P‐values < 0.05 were deemed significant; bars and error bars indicated the mean and SEM.