Table 8. PK Parameters in Rat and Dog for Lead Compounds.

compd	species	CLp (mL/min/kg)	CLb (mL/min/kg)	LBFa (%)	Vss (L)	t1/2 (h)	F (%)
13b	rat	12.8	23.7	30	0.39	0.7	64
13k	rat	16.0	27.6	35	0.60	1.1	20
14s	rat	14.0	35.0	44	0.21	1.0	31
14w	rat	11.7	20.9	26	0.50	1.0	82
16	rat	7.1	11.1	14	0.31	1.1	97
13b	dog	11.5	24.5	74	0.36	0.5	16
14w	dog	8.7	10.9	33	0.65	1.0	34
16	dog	10.0	15.9	48	0.63	0.9	32

^aLiver blood flows used: rat, 80 mL/min/kg; dog, 33 mL/min/kg.²²