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. 2022 Aug 26;16(10):15792–15804. doi: 10.1021/acsnano.2c04232

Figure 7.

Figure 7

Schematic of proposed two-stage mechanism for calcium-mediated adhesion and fusion between pMPC- LUVs and P. aeruginosa membrane. (1) Liposomes functionalized with pMPC reach the bacterial membrane, where the presence of divalent cations (yellow points) at the cell membrane’s surface bridges pMPC with LPS and pulls them toward the cell surface. (2) Fusion between liposome and bacterial membrane occurs due to charge–charge interaction (see text).