. 2022 Oct 29;15:11786469221122511. doi: 10.1177/11786469221122511

Table 5.

Comparison of enzymes of the kynurenine pathway of tryptophan metabolism across animal species.

Enzyme	Species comparisons	Source	[Reference]
TDO:	rat > guinea pig = mouse > rabbit	liver homogenate	Allegri et al⁷⁸
IDO:	rat > rabbit > guinea pig > mouse
KMO:	mouse > rat > guinea pig > rabbit
KAT:	rat > mouse > rabbit > guinea pig
KYNU:	guinea pig > rat > mouse > rabbit
3-HAAO:	guinea pig > rabbit > rat> mouse
ACMSD:	guinea pig > rat > mouse > rabbit
TDO:	pig > rat > turkey > chicken > mouse > frog > hamster > guinea pig > rabbit = gerbil > ox = sheep	liver homogenate	Badawy and Evans⁷
TDO:	rat > rabbit > mouse > gerbil	liver homogenate	Fujigaki et al¹⁷⁶
TDO:	mouse > dog > monkey > rat > human	Liver cytosol (based on Vmax)	Wang et al¹⁷⁴
TDO:	rat > rabbit > mouse > gerbil	liver	Murakami and Saito¹⁷⁷
IDO:	rabbit > gerbil > mouse > rat	lung
	gerbil > rabbit > mouse > rat	brain
KMO:	rat > gerbil > mouse > rabbit	liver
	Mouse > rat = gerbil > rabbit	lung
KYNU:	mouse > gerbil > rabbit > rat	liver
IDO1:	platypus > opossum > mouse	transfected cell lysates	Yuasa et al¹⁷⁸
IDO2:	platypus > mouse > opossum
TDO:	rat > cat	liver	DeCastro et al¹⁷⁹
KAT:	rat > cat	kidney
KMO:	cat > rat	liver, kidney
KYNU:	rat ⩾ cat	liver
	cat ⩾ rat	kidney
KYNU	Suncus (shrew) > rat > human	liver	Ishikawa et al¹⁸⁰
3-HAAO:	sunfish > bass > terrapin > chicken >	liver	Lan and Gholson¹⁸¹
frog > crayfish (zero)
ACMSD:	bass > sunfish > terrapin > frog > chicken	liver
AMSD:	frog > terrapin > chicken > sunfish	liver
3-HAAO:	rat > cat > beef	liver
ACMSD:	cat > rat > beef	liver
AMSD:	cat > rat = beef	kidney
KYNU:	rat ⩾ cat	liver	Ikeda et al⁵
3-HAAO:	rat > cat	liver
ACMSD:	cat > lizard > frog > cattle > pig > pigeon > rabbit > mouse > guinea pig > chicken > human > hamster > toad > rat	liver