Table 1. Dose, Formulation, and Pharmacokinetic Parameters of Pritelivir after Single Oral Administration to Various Species.
| species | dose | formulation | AUC [mg·h/L] | T1/2 [h] | F [%] |
|---|---|---|---|---|---|
| Rat | 1 mg/kg | Solution of pritelivir free base in 2.5% ethanol, 40% solutol, 57.5% aqua dest. | 12.9 | 5–10 | 65 |
| Dog | 1 mg/kg | Solution of pritelivir free base in PEG400 | 54.2 | 22–39 | 83 |
| Monkey | 1 mg/kg | Suspension of pritelivir free base in 0.5% aqueous methylcellulose solution (w/v) | 39.5 | 30 | 63 |
| Human | 100 mg | Tablet containing pritelivir mesylate, microcrystalline cellulose, croscarmellose sodium, mannitol, colloidal anhydrous silica, magnesium stearate, hydroxymethylpropyl cellulose, polyethylene glycol, and titanium dioxide | 90.8 | 60–70 | 73 |