Table 2. IC₅₀ in Human and Murine sEH and Microsomal Stability Values of 13–25.

^aReported IC₅₀ values are the average of three replicates. The fluorescent assay as performed here has a standard error between 10 and 20%, suggesting that differences of twofold or greater are significant. Because of limitations of the assay, it is difficult to distinguish among potencies <0.5 nM.³⁰

^bPercentage of remaining compound after 60 min of incubation with pooled human and mouse microsomes in the presence of NADPH at 37 °C.

^cND: not determined.