Table 5. Pharmacokinetic Parameters in Male CD1 Mice for Compounds 15 and 21 After 5 mg/kg sc Administrationa.
| compound | Dose | HL (h) | Tmax (h) | Cmax (μg/mL) | AUClast (μg*h/mL) | AUCINF (μg*h/mL) |
|---|---|---|---|---|---|---|
| 15 | 5 mg/Kg | 3.42 | 0.75 | 1.2 | 2.4 | 2.5 |
| 21 | 5 mg/Kg | 0.70 | 0.25 | 19.1 | 13.5 | 13.6 |
See the Experimental Section and Tables S4 and S5 and Figures S12 and S13 in the Supporting Information.