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. 2022 Oct 12;65(20):13660–13680. doi: 10.1021/acs.jmedchem.2c00515

Table 5. Pharmacokinetic Parameters in Male CD1 Mice for Compounds 15 and 21 After 5 mg/kg sc Administrationa.

compound Dose HL (h) Tmax (h) Cmax (μg/mL) AUClast (μg*h/mL) AUCINF (μg*h/mL)
15 5 mg/Kg 3.42 0.75 1.2 2.4 2.5
21 5 mg/Kg 0.70 0.25 19.1 13.5 13.6
a

See the Experimental Section and Tables S4 and S5 and Figures S12 and S13 in the Supporting Information.