Table 2:
Drugs prescription (% of patients) during hospital stay on 1st and 3rd waves.
| 1st wave | 3rd wave | P-value | |
|---|---|---|---|
| N | 1599 | 796 | |
| ACEI or ARB | 19.0 | 25.3 | <.001 |
| Interferon | 24.3 | 0.0 | <.001 |
| Hydroxychloroquine | 79.5 | 0.6 | <.001 |
| Lopinavir/ritonavir | 47.4 | 0.1 | <.001 |
| Azithromycin | 42.6 | 12.2 | <.001 |
| Any antibiotic | 73.8 | 52.8 | <.001 |
| Any antifungal | 2.8 | 3.9 | .1 |
| Anakinra | 3.0 | 3.9 | .2 |
| Other antiviral (except remdesivir) | 2.5 | 1.9 | .4 |
| Remdesivir | 0.0 | 2.4 | <.001 |
| Prednisone | 58.3 | 87.6 | <.001 |
| Tocilizumab | 17.0 | 35.1 | <.001 |
| Prednisone and/or tocilizumab | 59.5 | 88.1 | <.001 |
| Oral anticoagulant therapy (any) | 5.8 | 7.9 | .04 |
| Low molecular weight heparin | 54.7 | 83.3 | .03 |
ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker.