FIGURE 2.

The cycle of DNA methylation. The De novo methyltransferases, DNMT3A and DNMT3B paired with DNMT3L chaperon activity methylate unmethylated DNA templates at the CpG context. The maintenance mechanism ensures that hemi-methylated templated created during DNA replication are to be fully methylated on both DNA strands. DNMT1- DNA maintenance methyltransferase is responsible for that activity. Open lollipops represent unmethylated DNA, while painted lollipops represent the DNA that methylated.