Table 2 |.

Adverse events (grades 3 and 4)

Adverse event	Dose level 1 (n = 3)	Dose level 2 (n = 3)	Dose level 3 (n = 6)	All dose levels (%)
Anemia	3	3	6	12 (100)
Lymphopenia	3	3	6	12 (100)
Leukopenia	3	3	6	12 (100)
Neutropenia	3	3	6	12 (100)
Febrile neutropenia	2	2	4	8 (67)
Thrombocytopenia	2	2	4	8 (67)
Hypophosphatemia	2	1	3	6 (50)
Hyponatremia	0	1	3	4 (33)
Pulmonary edema	1	0	2	3 (25)
Hypoxia	1	0	2	3 (25)
Aspartate aminotransferase increased	0	1	2	3 (25)
Hypotension	1	0	1	2 (17)
Pleural effusion	0	1	1	2 (17)
Alanine aminotransferase increased	0	1	1	2 (17)
Hypokalemia	1	0	1	2 (17)
Catheter-related infection	0	0	1	1 (8)
Syncope	0	0	1	1 (8)
Pure red cell aplasia	1	0	0	1 (8)
Fever	0	0	1a	1 (8)
Acute kidney injury	0	0	1a	1 (8)
Respiratory failure	0	0	1a	1 (8)
Generalized muscle weakness	0	0	1a	1 (8)
Hyperkalemia	0	0	1a	1 (8)
Peripheral ischemia (lower extremity)	0	0	1a	1 (8)
Anxiety	0	0	1a	1 (8)
Blood bilirubin increased	0	0	1a	1 (8)
CPK increased	0	0	1a	1 (8)
Acidosis	0	0	1a	1 (8)
Delirium	0	0	1a	1 (8)
Dysphagia	0	0	1a	1 (8)
Hypertension	0	0	1a	1 (8)

^aOccurred in the same patient.