Fig. 22. Illustration of degrader technologies engaging the endosomal–lysosomal pathway. (A) M6P-LYTACs: M6P-LYTACs utilize a glycan tag binding with CI-M6PR to mark extracellular or transmembrane POI for intracellular lysosomal degradation following receptor-mediated internalization; (B) GalNAc-LYTACs & (C) MoDE-As utilize a glycan tag binding with the liver-specific ASGPR to mark POI for intracellular lysosomal degradation following receptor-mediated internalization.
