Table 3.
RIBEs caused by exosomes
| Donor cells | Recipient cells | Dose of radiation | Isolation method | Effect | References |
|---|---|---|---|---|---|
| Human non–small cell lung cancer cell lines (H460, H1299) | H460, H1299 | 5 Gy | UC | Exosomes communicated with adjacent cells | [23] |
| Human breast cancer cell line (MCF-7) | MCF-7 | 2 Gy | UC | Exosomes were partially involved in genomic instability | [79] |
| Human breast cancer cell line (MCF-7) | MCF-7 | 2 Gy | UC | Exosomal RNA and protein molecules were associated with RIBEs | [80] |
| Human embryonic lung fibroblasts (MRC-5) | MRC-5 | 2 Gy | UC | Exosomal miRNA-21 induced DNA damage and chromosome aberrations in bystander cells | [6] |
| Human papillomavirus– immortalized human bronchial epithelial (BEP2D), | BEP2D | 2 Gy | UC | Exosomal miR-7-5p mediated bystander autophagy | [86] |
| Human HNSCC cell lines (BHY, FaDu) | BHY, FaDu | 0–9 Gy | UC | Exosomes promoted the proliferation and radioresistance | [83] |
| Human papillomavirus– immortalized human bronchial epithelial (BEP2D), | BEP2D | 2 Gy | UC | Exosomal microRNAs contributed to DNA damage | [82] |
| Human umbilical-cord stromal stem cells (MSCs) | Human melanoma cell lines (A375, G361) and human breast cancer cell line (MCF-7) | 2 Gy | UC | Exosomes enhanced bystander tumor growth and metastasis | [52] |
| BALB/C mouse–derived mammary carcinoma (TSA) | DCs | 8 Gy | UC | Exosomes transferred anti-tumor effects to bystander cells | [81] |
| Human breast cancer cell line (MCF-7) | MCF-7 | 2 Gy | UC | Exosomes enhanced invasiveness of bystander cells | [30] |
HNSCC, head and neck squamous cell carcinoma; DCs, dendritic cells; UC, ultracentrifugation