Cytotoxicity of the FOLFIRINOX-loaded Christmas tree-shaped MNs on Capan1 cells and PC organoids. (a) Live and dead staining of the Capan1 cells from different groups. (b) Statistical results of the relative cell viability after different treatment at 0, 24, 48, and 72 h. (c) Live and dead staining of the patient-derived pancreatic tumor organoids. (d) Statistical results of the relative organoid viability after different treatments at 0, 24, 48, and 72 h. Scale bar is 50 μm in (a) and (c).