Fig. 2.
GCVsig and DNA damage response is associated with ganciclovir (GCV) but not acyclovir (ACV) treatment. A C > A mutational spectra from whole-genome sequenced (WGS) H414 cell lines treated with vehicle (DMSO), 100 µM ACV, and 100 µM GCV. B Contribution of CA > AA mutations across replicates from WGS of control and 5 µM ACV- and 5 µM GCV-treated murine myeloid cells. The mean is shown and statistical significance determined by Student’s t-test (** p < 0.01, n.s. not significant). C 4′,6-Diamidino-2-phenylindole (DAPI) and γ-H2AX staining of H414 cells treated with vehicle (DMSO), 500 µM hydroxyurea, 100 µM GCV, and 100 µM ACV