Table 3.
Association between exposure to procedures requiring anesthesia before age 3 and incidence of autism spectrum disorder
| Anesthetic characteristics | Matched analysis without additional covariates |
Matched analysis, covariate adjusted |
||
|---|---|---|---|---|
| Odds ratio (95% CI) |
p | Odds ratio (95% CI) |
p | |
| Any anesthetic exposure | < .001 | 0.149 | ||
| No | 1.00 | 1.00 | ||
| Yes | 1.94 (1.49–2.52) | 1.27 (0.92–1.76) | ||
| Number of anesthetic exposures | < .001 | 0.144 | ||
| No exposure | 1.00 | 1.00 | ||
| 1 exposure | 1.88 (1.39–2.54) | 1.39 (0.98–1.98) | ||
| ≥ 2 exposures | 2.09 (1.33–3.31) | 0.93 (0.53–1.64) | ||
| Cumulative duration, per 30 mina | 1.08 (1.03–1.12) | < .001 | 0.99 (0.95–1.04) | 0.772 |
| Categorical duration | < .001 | 0.337 | ||
| No exposure | 1.00 | 1.00 | ||
| < 60 min | 1.62 (1.10–2.39) | 1.25 (0.79–1.98) | ||
| ≥ 60 min | 2.19 (1.58–3.05) | 1.29 (0.87–1.91) | ||
Analysis performed using conditional logistic regression taking into account the 1:2 matched set study design (matched on sex, date of birth (± 90 days), and mother’s age at the time of birth (± 2 years)). Additional covariates in the adjusted analysis include birth weight and health status as measured using the Adjusted Clinical Groups (ACG)® Case-Mix System
a
Cumulative duration of exposure to anesthetic before age 3 was analyzed as a continuous variable, with the odds ratio presented for a 30 min increase