Table 5.
Measured values (median and inter-quantile range in the bracket) of DCE kinetic parameters (Ktrans, Fp,Vp, Ve, PS) derived from (Tofts, Ex-Tofts, ATH, SC, and DP models) in cervical cancer and normal cervix tissue, and the corresponding p-values of Mann–Whitney U test.
| Ktrans (min−1) | Fp (ml/min/100 ml) | Vp (ml/100 ml) | Ve (ml/100 ml) | PS (ml/min/100 ml) | |
|---|---|---|---|---|---|
| Tofts model | |||||
| Cervix lesion | |||||
| Center 1 | 0.09 (0.08,0.13) | – | – | 13.91 (11.32,17.30) | – |
| Center 2 | 0.13 (0.08,0.19) | – | – | 13.97 (10.07,17.61) | – |
| Z value | -1.858 | – | – | -0.074 | – |
| P value | 0.063 | – | – | 0.941 | – |
| Normal tissue | – | – | – | ||
| Center 1 | 0.11 (0.07,0.14) | – | – | 30.74 (22.40,42.62) | – |
| Center 2 | 0.12 (0.08,0.16) | – | – | 28.46 (19.29,39.73) | – |
| Z value | -1.595 | -1.350 | |||
| P value | 0.111 | – | – | 0.177 | – |
| Ex-Tofts model | |||||
| Cervix lesion | |||||
| Center 1 | 0.07 (0.05,0.10) | – | 1.71 (1.21,2.34) | 12.65 (10.05,17.30) | – |
| Center 2 | 0.10 (0.06,0.16) | – | 1.45 (1.02,2.20) | 14.04 (11.14,17.78) | – |
| Z value | -2.066 | – | -1.042 | -1.589 | – |
| P value | 0.039 | – | 0.297 | 0.112 | – |
| Normal tissue | – | – | |||
| Center 1 | 0.09 (0.05,0.12) | – | 1.08 (0.27,2.06) | 33.75 (24.63,45.38) | – |
| Center 2 | 0.10 (0.07,0.13) | – | 1.72 (0.93,2.80) | 29.77 (19.93,41.44) | – |
| Z value | -1.333 | -1.827 | -2.220 | ||
| P value | 0.182 | – | 0.068 | 0.026 | – |
| ATH model | |||||
| Cervix lesion | |||||
| Center 1 | 21.88 (17.82,35.43) | 2.43 (1.26,4.03) | 11.16 (9.17,15.58) | 7.10 (4.78,9.54) | |
| Center 2 | 26.36 (18.03,36.74) | 2.64 (1.64,3.97) | 12.32 (8.62,17.35) | 9.44 (5.61,13.21) | |
| Z value | -.897 | -.707 | -.175 | -1.924 | |
| P value | 0.370 | 0.479 | 0.861 | 0.054 | |
| Normal tissue | |||||
| Center 1 | 39.25 (31.65,51.61) | 1.00 (0.39,2.56) | 33.89 (23.94,45.93) | 9.57 (5.70,13.34) | |
| Center 2 | 35.37 (24.98,46.73) | 2.72 (1.43,6.29) | 27.52 (18.14,38.91) | 9.74 (6.43,14.76) | |
| Z value | -1.908 | -3.645 | -2.197 | -0.853 | |
| P value | P=0.056 | P< 0.001 | 0.028 | 0.394 | |
| SC model | |||||
| Cervix lesion | |||||
| Center 1 | 15.26 (12.61,21.78) | 6.12 (4.00,8.62) | 8.74 (6.36,14.14) | 4.76 (2.73,8.29) | |
| Center 2 | 19.06 (15.40,30.82) | 6.39 (5.01,8.27) | 10.88 (6.68,19.83) | 5.52 (3.13,10.82) | |
| Z value | -2.791 | -0.197 | -0.867 | -0.878 | |
| P value | 0.005 | 0.844 | 0.386 | 0.380 | |
| Normal tissue | |||||
| Center 1 | 16.65 (12.15,20.51) | 5.70 (2.99,9.91) | 26.39 (19.25,39.25) | 13.47 (6.61,22.14) | |
| Center 2 | 22.14 (15.96,34.69) | 8.49 (5.42,12.58) | 31.11 (18.25,46.92) | 9.39 (6.37,16.73) | |
| Z value | -3.512 | -2.321 | -0.425 | -1.734 | |
| P value | P< 0.001 | 0.02 | 0.671 | 0.083 | |
| DP model | |||||
| Cervix lesion | |||||
| Center 1 | 13.83 (11.64,17.00) | 3.04 (2.08,5.37) | 10.56 (8.63,14.83) | 6.81 (4.92,9.33) | |
| Center 2 | 14.81 (0.05,0.10) | 4.04 (3.43,6.14) | 10.48 (7.73,15.39) | 8.31 (5.68,12.22) | |
| Z value | -1.455 | -2.099 | -0.462 | -1.012 | |
| P value | 0.146 | 0.036 | 0.644 | 0.311 | |
| Normal tissue | |||||
| Center 1 | 13.93 (0.08,0.13) | 3.77 (1.80,6.03) | 29.82 (23.59,39.35) | 11.63 (6.21,17.87) | |
| Center 2 | 16.22 (11.27,22.54) | 5.58 (4.09,8.80) | 24.52 (17.35,35.95) | 11.46 (7.30,14.95) | |
| Z value | -2.017 | -3.226 | -2.208 | -0.801 | |
| P value | .044 | 0.001 | .027 | .423 |