Table 8.
Differential Metabolites in Fecal Tissues
| Metabolite Classification | Metabolite | NC/UC | SYD/UC | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Superclass | Class | P value | Q value | VIP | Fold Change (NC/UC) | P value | Q value | VIP | Fold Change (SYD/UC) | |
| Fatty Acyls | Fatty aldehydes | Pentadecanal | 0.0011 | 0.0023 | 3.37 | 0.00 | 0.0025 | 0.0102 | 4.05 | 0.29 |
| Lipids and lipid-like molecules | Fatty Acyls | 15-Hentriacontanol | 0.0000 | 0.0000 | 7.32 | 6.63 | 0.0118 | 0.0332 | 4.10 | 2.27 |
| DG(13D5/11D5/0:0) | 0.0000 | 0.0000 | 2.08 | 0.02 | 0.0000 | 0.0002 | 2.48 | 0.36 | ||
| Heptadecanoic acid | 0.0006 | 0.0015 | 1.13 | 0.02 | 0.0011 | 0.0055 | 1.49 | 0.28 | ||
| Glycerolipids | MG(0:0/16:0/0:0) | 0.0025 | 0.0049 | 1.79 | 0.00 | 0.0164 | 0.0427 | 1.71 | 0.41 | |
| Glycerophospholipids | LysoPE(0:0/15:0) | 0.0000 | 0.0002 | 1.17 | 0.41 | 0.0056 | 0.0187 | 1.01 | 0.71 | |
| PE(P-16:0e/0:0) | 0.0013 | 0.0028 | 1.51 | 0.25 | 0.0115 | 0.0326 | 2.03 | 0.50 | ||
| PC(18:0/20:4(5Z,8Z,11Z,14Z)) | 0.0015 | 0.0031 | 1.79 | 0.00 | 0.0033 | 0.0126 | 2.14 | 0.28 | ||
| LysoPC(17:0) | 0.0064 | 0.0110 | 1.37 | 0.20 | 0.0004 | 0.0024 | 2.64 | 0.20 | ||
| LysoPC(18:0) | 0.0000 | 0.0000 | 1.16 | 3.16 | 0.0007 | 0.0038 | 1.04 | 2.15 | ||
| Prenol lipids | Soyasaponin V | 0.0002 | 0.0005 | 2.63 | 0.09 | 0.0001 | 0.0012 | 3.73 | 0.27 | |
| Jujuboside B | 0.0000 | 0.0000 | 9.03 | 0.01 | 0.0000 | 0.0002 | 12.21 | 0.28 | ||
| Soyasaponin I | 0.0001 | 0.0002 | 1.11 | 0.03 | 0.0001 | 0.0008 | 1.60 | 0.29 | ||
| Pisumsaponin I | 0.0000 | 0.0000 | 2.23 | 4.74 | 0.0068 | 0.0217 | 1.18 | 1.75 | ||
| Myricolal | 0.0000 | 0.0000 | 2.83 | 0.02 | 0.0000 | 0.0001 | 3.60 | 0.34 | ||
| Pisumsaponin II | 0.0002 | 0.0005 | 4.29 | 0.02 | 0.0003 | 0.0022 | 5.59 | 0.29 | ||
| (17alpha,23S)-Epoxy-28,29-dihydroxy-27-norlanost-8-ene-3,24-dione | 0.0000 | 0.0001 | 2.54 | 0.35 | 0.0043 | 0.0155 | 2.19 | 0.69 | ||
| Camellenodiol | 0.0038 | 0.0069 | 1.36 | 0.00 | 0.0052 | 0.0178 | 1.65 | 0.24 | ||
| Glyuranolide | 0.0032 | 0.0061 | 1.14 | 0.00 | 0.0045 | 0.0160 | 1.50 | 0.26 | ||
| Sphingolipids | Sphingosine 1-phosphate | 0.0000 | 0.0001 | 1.42 | 0.35 | 0.0003 | 0.0020 | 1.37 | 0.60 | |
| Steroids and steroid derivatives | 7-Sulfocholic acid | 0.0000 | 0.0000 | 11.19 | 2.70 | 0.0141 | 0.0383 | 7.61 | 1.54 | |
| 1-a,24R,25-Trihydroxyvitamin D2 | 0.0000 | 0.0000 | 1.41 | 0.09 | 0.0000 | 0.0002 | 1.50 | 0.39 | ||
| (3beta,5alpha,6alpha,7alpha,22E,24R)-5,6-Epoxyergosta-8,14,22-triene-3,7-diol | 0.0000 | 0.0000 | 1.51 | 3.61 | 0.0039 | 0.0142 | 1.14 | 1.86 | ||
| Ganodosterone | 0.0000 | 0.0000 | 1.25 | 0.02 | 0.0001 | 0.0007 | 1.38 | 0.37 | ||
| 6-Deoxohomodolichosterone | 0.0000 | 0.0000 | 1.29 | 0.05 | 0.0051 | 0.0174 | 1.50 | 0.49 | ||
| 7-Ketodeoxycholic acid | 0.0000 | 0.0000 | 1.35 | 0.03 | 0.0000 | 0.0003 | 1.70 | 0.31 | ||
| Organic acids and derivatives | Keto acids and derivatives | Phaseolic acid | 0.0000 | 0.0001 | 1.03 | 0.47 | 0.0006 | 0.0033 | 1.08 | 0.68 |
| Organic nitrogen compounds | Organonitrogen compounds | Sphinganine | 0.0002 | 0.0005 | 2.48 | 0.01 | 0.0000 | 0.0004 | 3.60 | 0.15 |
| Organic oxygen compounds | Organooxygen compounds | 1-Phenyl-1,3-heptadecanedione | 0.0000 | 0.0001 | 1.26 | 0.36 | 0.0002 | 0.0013 | 1.35 | 0.60 |
| Organoheterocyclic compounds | Benzopyrans | Austalide I | 0.0001 | 0.0002 | 1.55 | 0.04 | 0.0005 | 0.0023 | 1.79 | 0.34 |
| Heteroaromatic compounds | Ethyl 3-[(2-furanylmethyl)thio]propanoate | 0.0130 | 0.0208 | 1.54 | 0.04 | 0.0020 | 0.0086 | 2.61 | 0.11 | |
| Tetrapyrroles and derivatives | (-)-Stercobilin | 0.0000 | 0.0000 | 6.81 | 8.26 | 0.0074 | 0.0231 | 4.19 | 2.86 | |
| Piperidines | Repaglinide | 0.0000 | 0.0000 | 2.34 | 4.66 | 0.0200 | 0.0498 | 1.66 | 2.29 | |
| Organosulfur compounds | Organic trisulfides | Allitridin | 0.0001 | 0.0003 | 1.03 | 0.50 | 0.0002 | 0.0013 | 1.54 | 0.64 |
| Phenylpropanoids and polyketides | Flavonoids | Naringenin | 0.0003 | 0.0009 | 4.70 | 0.00 | 0.0028 | 0.0112 | 5.07 | 0.35 |
| Homoisoflavonoids | 7-Hydroxy-3-(3-hydroxy-4-methoxybenzyl)-5-methoxy-4-chromanone | 0.0212 | 0.0321 | 1.76 | 0.06 | 0.0021 | 0.0088 | 3.18 | 0.05 | |
| Isoflavonoids | Ganoderic acid L | 0.0000 | 0.0001 | 6.39 | 0.01 | 0.0000 | 0.0002 | 8.52 | 0.27 | |
| Phenylpropanoic acids | Suprofen S-oxide | 0.0002 | 0.0005 | 1.56 | 0.02 | 0.0001 | 0.0009 | 2.14 | 0.21 | |