Table 12.
Metabolic Pathways of SYD During the Treatment of UC
| Sample | Pathway | P value | -LOG10(p) | Impact |
|---|---|---|---|---|
| Feces | Glycerophospholipid metabolism | 0.0273 | 1.56 | 0.22 |
| Sphingolipid metabolism | 0.0563 | 1.25 | 0.18 | |
| Drug metabolism - other enzymes | 0.5143 | 0.29 | 0.07 | |
| Primary bile acid biosynthesis | 0.5838 | 0.23 | 0.02 | |
| Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 0.2320 | 0.63 | 0.00 | |
| Linoleic acid metabolism | 0.0897 | 1.05 | 0.00 | |
| Taurine and hypotaurine metabolism | 0.1397 | 0.85 | 0.00 | |
| Alpha-Linolenic acid metabolism | 0.2173 | 0.66 | 0.00 | |
| Retinol metabolism | 0.2605 | 0.58 | 0.00 | |
| Arachidonic acid metabolism | 0.4952 | 0.31 | 0.00 | |
| Livers | Pentose phosphate pathway | 0.0710 | 1.15 | 0.13 |
| Glycerophospholipid metabolism | 0.1141 | 0.94 | 0.09 | |
| Primary bile acid biosynthesis | 0.1439 | 0.84 | 0.02 | |
| Linoleic acid metabolism | 0.0165 | 1.78 | 0.00 | |
| Taurine and hypotaurine metabolism | 0.0263 | 1.58 | 0.00 | |
| Alpha-Linolenic acid metabolism | 0.0425 | 1.37 | 0.00 | |
| Pentose and glucuronate interconversions | 0.0584 | 1.23 | 0.00 | |
| Arachidonic acid metabolism | 0.1141 | 0.94 | 0.00 | |
| Serum | Alpha-Linolenic acid metabolism | 0.0019 | 2.73 | 0.33 |
| Glycerophospholipid metabolism | 0.1764 | 0.75 | 0.09 | |
| Biosynthesis of unsaturated fatty acids | 0.0142 | 1.85 | 0.00 | |
| Linoleic acid metabolism | 0.0263 | 1.58 | 0.00 | |
| Arachidonic acid metabolism | 0.1764 | 0.75 | 0.00 | |
| Urine | Phenylalanine, tyrosine and tryptophan biosynthesis | 0.1643 | 0.78 | 0.50 |
| Tyrosine metabolism | 0.2785 | 0.56 | 0.26 | |
| Pantothenate and CoA biosynthesis | 0.5755 | 0.24 | 0.24 | |
| Arachidonic acid metabolism | 0.4742 | 0.32 | 0.10 | |
| Drug metabolism - other enzymes | 0.8218 | 0.09 | 0.07 | |
| Steroid hormone biosynthesis | 0.8633 | 0.06 | 0.06 | |
| Citrate cycle (TCA cycle) | 0.5943 | 0.23 | 0.04 | |
| Pyruvate metabolism | 0.6295 | 0.20 | 0.03 | |
| Phenylalanine metabolism | 0.0941 | 1.03 | 0.00 | |
| Ubiquinone and other terpenoid-quinone biosynthesis | 0.3326 | 0.48 | 0.00 | |
| Glyoxylate and dicarboxylate metabolism | 0.7653 | 0.12 | 0.00 | |
| Tryptophan metabolism | 0.8448 | 0.07 | 0.00 | |
| Fatty acid biosynthesis | 0.8823 | 0.05 | 0.00 | |
| Aminoacyl-tRNA biosynthesis | 0.8877 | 0.05 | 0.00 | |
| Metabolism of xenobiotics by cytochrome P450 | 0.9467 | 0.02 | 0.00 |
Note: Metabolic pathways with impact > 0.1 are indicated in bold.