Figure 1.

Overview of imaginal disc regeneration. (A) Cartoon of a wing imaginal disc showing the different territories of the disc. The notum generates the thoracic wall while the hinge and pouch generate progressively more distal structures of the wing, respectively. (B) Imaginal disc cellular architecture: the disc resembles a flattened sac with the two layers, the disc proper and the peripodial epithelium being continuous around the edges. The apical domain of both epithelial layers face inward toward the lumen. The cells of the disc proper are columnar, while the cells of the peripodial epithelium are squamous. (C) Physical damage of imaginal discs: early responses are best observed in culture while later responses are observed following transplantation into adult abdomens and subsequent and recovery. (D) Genetic tissue ablation models allow more precisely defined ablation regions and for the study of disc regeneration in its natural environment.