Table 1:

Comparison of characteristics among respondents who did or did not developed severe cognitive impairment (CASI score <60) by exam 4.

	SCI+ (n=189)	SCI− (n=3,393)
Characteristic	Mean (SD), % (#)	Mean (SD), % (#)	P value*	OR (95% CI)†
Age at exam 1, years	58.4 (5.4)	52.3 (4.4)	<.0001	1.256 (1.22–1.29)
Education, years	8.0 (2.9)	10.6 (3.2)	<.0001	0.731 (0.69–0.77)
Systolic blood pressure, mmHg	134.0 (21.4)	129.8 (18.3)	.0094	1.011 (1.00–1.02)
Body mass index, kg/m2	23.8 (3.0)	23.9 (2.8)	.7226	0.991 (0.94–1.04)
Cholesterol, mmol/L	5.6 (0.9)	5.7 (0.9)	.5239	0.949 (0.81–1.12)
Physically active	92.1% (174)	82.6% (2,803)	.0007	2.441 (1.43–4.17)
APOE ε4 carrier	19.6% (37)	18.4% (625)	.6902	1.078 (0.75–1.56)
CAIDE score	9.49 (2.0)	7.21 (2.4)	<.0001	1.477 (1.39–1.58)

Abbreviations: APOE ε4, apolipoprotein allele ε4; CASI, Cognitive Abilities Screening Instrument; CI, confidence interval; kg/m2, kilograms per meter squared; mmHg, millimeters of mercury; mmol/L, millimoles per liter; OR, odds ratio; SCI, severe cognitive impairment; SD, standard deviation.

NOTE: Bolding indentifies significant results.

^*P value for Satterthwaite t value or Pearson chi-square.

^†Odds ratio (OR) and 95% confidence interval (95% CI) for parameter estimate.