Table 3.

MIXL Model Results for the Three Different Arms

Attribute: Level		Arm 1: Failure Framing					Arm 2: Effectiveness Framing					Arm 3: Failure and Effectiveness Frames
		Β-coeff	SE	95% CI		P	Β-coeff	SE	95% CI			Β-coeff	SE	95% CI		P
				Lower	Upper				Lower	Upper	P			Lower	Upper
Contribution to Resistance: Low	(ref)
Contribution to Resistance: Med	Mean	−0.9913	0.0861	−1.1601	−0.8226	<0.001	−1.0338	0.1037	−1.2370	−0.8306	<0.001	−0.9546	0.0950	−1.1408	−0.7684	<0.001
	SD	−0.7150	0.1074	−0.9256	−0.5045	<0.001	1.2542	0.1180	1.0228	1.4855	<0.001	0.9426	0.1024	0.7419	1.1432	<0.001
Contribution to Resistance: High	Mean	−2.6755	0.2000	−3.0674	−2.2836	<0.001	−2.6670	0.2062	−3.0711	−2.2630	<0.001	−2.6057	0.2021	−3.0019	−2.2095	<0.001
	SD	2.4438	0.1674	2.1157	2.7719	<0.001	2.6875	0.1942	2.3069	3.0681	<0.001	2.6684	0.1882	2.2994	3.0373	<0.001
TX Duration: 3 days	(ref)
TX Duration: 7 days	Mean	0.1455	0.0659	0.0163	0.2747	0.027	−0.0089	0.0705	−0.1471	0.1292	0.899	−0.0236	0.0685	−0.1579	0.1106	0.730
	SD	−0.0431	0.2324	−0.4987	0.4125	0.853	−0.3488	0.1502	−0.6432	−0.0545	0.020	0.0501	0.1492	−0.2422	0.3425	0.737
TX Duration: 14 days	Mean	−0.4154	0.0744	−0.5611	−0.2696	<0.001	−0.3295	0.0748	−0.4762	−0.1829	<0.001	−0.4547	0.0749	−0.6014	−0.3080	<0.001
	SD	−0.5871	0.0892	−0.7620	−0.4122	<0.001	−0.3460	0.1463	−0.6329	−0.0592	0.018	−0.5708	0.0984	−0.7637	−0.3779	<0.001
Likelihood of Side-Effects: 1%
Likelihood of Side-Effects: 5%	Mean	−0.3045	0.0880	−0.4770	−0.1319	0.001	−0.6217	0.0855	−0.7892	−0.4542	<0.001	−0.2715	0.0928	−0.4535	−0.0895	0.003
	SD	−0.2637	0.2468	−0.7475	0.2201	0.285	−0.0002	0.2128	−0.4173	0.4170	0.999	0.3210	0.2501	−0.1693	0.8112	0.199
Likelihood of Side-Effects: 10%	Mean	−0.4389	0.0845	−0.6045	−0.2733	<0.001	−1.0859	0.0945	−1.2711	−0.9006	<0.001	−0.7603	0.0997	−0.9557	−0.5648	<0.001
	SD	0.1698	0.2123	−0.2463	0.5859	0.424	−0.1348	0.5007	−1.1161	0.8465	0.788	−0.2128	0.2407	−0.6846	0.2590	0.377
Likelihood of Side-Effects: 20%	Mean	−1.0981	0.1192	−1.3318	−0.8644	<0.001	−1.7286	0.1357	−1.9945	−1.4627	<0.001	−1.3655	0.1384	−1.6368	−1.0943	<0.001
	SD	1.0129	0.1109	0.7954	1.2303	<0.001	1.2727	0.1312	1.0156	1.5298	<0.001	1.2574	0.1281	1.0063	1.5085	<0.001
TX Effectiveness/Failure: 95%/5%	(ref)
TX Effectiveness/Failure: 90%/10%	Mean	−0.3778	0.1356	−0.6435	−0.1121	0.005	−0.1923	0.1803	−0.5457	0.1612	0.286	0.1481	0.2841	−0.4087	0.7050	0.602
	SD	0.6172	0.1930	0.2389	0.9954	0.001	0.2578	0.3639	−0.4554	0.9709	0.479	0.5386	0.1862	0.1736	0.9036	0.004
TX Effectiveness/Failure: 85%/15%	Mean	−0.8237	0.1479	−1.1136	−0.5338	<0.001	−0.3279	0.2000	−0.7198	0.0641	0.101	−0.5427	0.2805	−1.0924	0.0071	0.053
	SD	0.3907	0.2794	−0.1569	0.9382	0.162	−0.3083	0.3792	−1.0515	0.4349	0.416	−0.2530	0.3208	−0.8818	0.3759	0.430
TX Effectiveness/Failure: 80%/20%	Mean	−1.0964	0.1572	−1.4045	−0.7882	<0.001	−0.8442	0.1923	−1.2212	−0.4672	<0.001	−0.7732	0.0956	−0.9605	−0.5859	<0.001
	SD	1.0496	0.1407	0.7739	1.3253	<0.001	−0.4985	0.3851	−1.2532	0.2562	0.195	0.9375	0.1172	0.7078	1.1672	<0.001
Cost: €10	(ref)
Cost: €25	Mean	−0.2694	0.0861	−0.4381	−0.1008	0.002	−0.2374	0.0836	−0.4012	−0.0735	0.005	−0.2729	0.0792	−0.4282	−0.1176	0.001
	SD	−0.0693	0.2002	−0.4617	0.3230	0.729	0.0360	0.2267	−0.4084	0.4804	0.874	−0.0515	0.1750	−0.3944	0.2915	0.769
Cost: €40	Mean	−0.9274	0.1011	−1.1255	−0.7293	<0.001	−0.6950	0.0897	−0.8708	−0.5192	<0.001	−0.8999	0.1050	−1.1057	−0.6940	<0.001
	SD	−0.6175	0.1274	−0.8673	−0.3677	<0.001	−0.3837	0.2025	−0.7806	0.0132	0.058	0.8021	0.1104	0.5858	1.0184	<0.001
Cost: €100	Mean	−2.5514	0.2230	−2.9885	−2.1143	<0.001	−2.6364	0.2038	−3.0358	−2.2371	<0.001	−2.8258	0.2181	−3.2533	−2.3982	<0.001
	SD	2.7336	0.1913	2.3586	3.1085	<0.001	2.6289	0.2064	2.2243	3.0335	<0.001	2.8260	0.2025	2.4291	3.2230	<0.001
Log-likelihood		−3091.3249					−2783.2115					−3057.4523

Notes: T_X: Treatment parameters with significant random effects are shown with SD.

Abbreviations: SD, standard deviation; SE, standard error.