Table 4.

Attribute-Level Estimates for the MIXL Model of the Pooled Results from All Arms

Attribute: Level		β-coeff	SE	95% CI		P
				Lower	Upper
Contribution to Resistance: Low	(ref)
Contribution to Resistance: Med	Mean	−0.9805	0.0526	−1.0837	−0.8774	<0.001
	SD	0.9669	0.0612	0.8471	1.0868	<0.001
Contribution to Resistance: High	Mean	−2.5970	0.1112	−2.8151	−2.3790	<0.001
	SD	2.5959	0.1059	2.3884	2.8034	<0.001
TX Duration: 3 days*	(ref)
TX Duration: 7 days*	Mean	0.1623	0.0649	0.0352	0.2894	0.012
	SD	−0.0424	0.1590	−0.3541	0.2693	0.790
TX Duration: 14 days*	Mean	−0.3765	0.0691	−0.5119	−0.2411	<0.001
	SD	−0.5161	0.0585	−0.6309	−0.4014	<0.001
Likelihood of Side-Effects: 1%*	(ref)
Likelihood of Side-Effects: 5%*	Mean	−0.3455	0.0843	−0.5106	−0.1803	<0.001
	SD	−0.1442	0.1605	−0.4588	0.1704	0.369
Likelihood of Side-Effects: 10%*	Mean	−0.4081	0.0773	−0.5596	−0.2566	<0.001
	SD	−0.1898	0.1652	−0.5135	0.1339	0.251
Likelihood of Side-Effects: 20%*	Mean	−1.0219	0.1064	−1.2305	−0.8132	<0.001
	SD	1.1816	0.0699	1.0446	1.3186	<0.001
TX Effectiveness/Failure: 95%/5%	(ref)
TX Effectiveness/Failure: 90%/10%	Mean	−0.1770	0.0879	−0.3492	−0.0048	0.044
	SD	0.5362	0.1732	0.1967	0.8756	0.002
TX Effectiveness/Failure: 85%/15%	Mean	−0.6337	0.0935	−0.8169	−0.4506	<0.001
	SD	0.2842	0.3465	−0.3950	0.9635	0.412
TX Effectiveness/Failure: 80%/20%	Mean	−0.8753	0.0706	−1.0136	−0.7370	<0.001
	SD	0.9317	0.0813	0.7724	1.0911	<0.001
Cost: €10	(ref)
Cost: €25	Mean	−0.2265	0.0455	−0.3157	−0.1374	<0.001
	SD	−0.0354	0.1158	−0.2624	0.1916	0.760
Cost: €40	Mean	−0.8017	0.0532	−0.9059	−0.6975	<0.001
	SD	−0.6719	0.0700	−0.8092	−0.5347	<0.001
Cost: €100	Mean	−2.6369	0.1189	−2.8700	−2.4039	<0.001
	SD	2.7628	0.1153	2.5368	2.9887	<0.001
Interaction effects (Frame*Parameter)ᵜ
Effectiveness*Duration: 7 days	Mean	−0.1595	0.0932	−0.3421	0.0232	0.087
Combination*Duration: 7 days	Mean	−0.2188	0.0925	−0.4001	−0.0375	0.018
Effectiveness*Duration: 14 days	Mean	0.0266	0.0996	−0.1687	0.2219	0.789
Combination*Duration: 14 days	Mean	−0.0783	0.0982	−0.2707	0.1141	0.425
Effectiveness*Side-Effects: 5%	Mean	−0.2160	0.1160	−0.4434	0.0113	0.063
Combination*Side-Effects: 5%	Mean	0.0361	0.1216	−0.2023	0.2746	0.766
Effectiveness*Side-Effects: 10%	Mean	−0.6317	0.1144	−0.8559	−0.4074	<0.001
Combination*Side-Effects: 10%	Mean	−0.3367	0.1145	−0.5611	−0.1123	0.003
Effectiveness*Side-Effects: 20%	Mean	−0.6517	0.1518	−0.9493	−0.3541	<0.001
Combination*Side-Effects: 20%	Mean	−0.3578	0.1511	−0.6539	−0.0616	0.018
Log-likelihood		−8967.0286

Notes: Parameters with significant random effects are shown with SD; *β Coefficients are for the reference Arm 1 (Failure); T_X: Treatment, ᵜAll interaction effects were included in the final MIXL model as fixed effects, so no SDs are shown.