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Percent negative CpG-GE associations by gene region.
With the exception of 3’ untranslated regions (UTRs), the majority of cis CpG-GE relationships were negative across gene regions in both the AYATS (red) and PREG (blue) cohorts. Promoters and 5’ UTRs had the highest fraction of negative associations, aligning with canonical descriptions of promoter DNAm as a repressor of local gene transcription.
