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. 2022 Jun 13;17(12):1753–1773. doi: 10.1080/15592294.2022.2079293

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — Absolute distance between CpG probes and transcriptional start sites (TSS) of proximal genes. A density plot depicting the absolute distance of DNA methylation microarray probes (darker colour) relative to the GE-associated CpG sites (lighter colour) from the transcriptional start sites of cis genes. Both the AYATS (red) and PREG (blue) cohorts showed enrichment in areas flanking active transcription. The proportion of GE-associated CpGs compared to the CpGs represented on the microarray was highest in areas directly downstream of the TSS.