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. 2022 Oct 26;19(1):1115–1129. doi: 10.1080/15476286.2022.2139110

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — PRKCE variants data retrieved from different databases (ENSEMBL, COSMIC, EVS, and genomeAD). (A) Total variants obtained for PRKCE gene from all databases were 346, 853. Out of which 376 were UTR variants. b(B) Number of variants belonging to different consequences, retrieved from different databases. c(C) UTR (3’ and 5’) variant number obtained from different databases. Among these 256 and 82 unique 5’ and 3’ UTR variants were sorted, respectively. 5'UTRs are highlighted with green and 3’ UTRs are highlighted with red. d(D) 5'UTR variation frequency and (Ee) heatmap for mutational hotspot. (Ff) 3'UTR variation frequency and (G) heatmap for mutational hotspot.