Figure 3.

Impact of PRKCE UTR variations on the transcription binding sites of the gene. (A) Most of the PRKCE 5'UTR variants caused the deletion of the transcription factor binding sites and most 3'UTR variants did not have impact on transcription factor binding sites. (B) Graph representing the transcription factor binding sites introduced due to UTR variations. (C) Venn diagram representation of the transcription factor binding site specifically present in Wildtype and mutated sequences and common is both wildtype and mutated PRKCE gene sequence due to 5’ and 3’ UTR variation. (D) Co-regulation mechanism of transcription factors in different tissues in humans. Transcription factors in red box represent sites present at 5'UTR and in green box depicts 3'UTR sites. Number written next to transcription factor complex indicates -LogP value where higher value indicates significance.