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. 2022 Oct 26;19(1):1115–1129. doi: 10.1080/15476286.2022.2139110

Figure 4.

Figure 4.

KEGG constructed pathway for the regulation of PKCε gene transcription. Cell signalling cascades such as WNT pathway, IL pathway, and EGFR/RAS/RAF pathway contributes to the activation of transcription factors that may bind with the transcription factor binding sites on PRKCE UTRs and regulate its transcription. PKCε also phosphorylates and activates RAF, through which PKCε may drive a positive feedback loop.