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. 2022 Oct 26;19(1):1115–1129. doi: 10.1080/15476286.2022.2139110

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — PRKCE UTR variants influence on the mRNA secondary structure. Minimum free energy (MFE) scores for both wildtype sequence and variant sequence for (A) 5'UTR variation and (B) 3'UTR variations are plotted. Lower the MFE score, higher the structure stability. (C) Number of PRKCE UTR variants affecting the mRNA stability. Major number of 5'UTR as well as 3'UTR variants decreased the mRNA structural stability. Variants that increased the mRNA stability are depicted with dotted-red square, whereas variants that decreased stability are highlighted with dotted-green square.