Table 2.
Transcription factor binding sites (TFBS) along with the respective transcription factors and the TFBS role in transcription and pathway involve in transcription factor regulation.
| Transcription factor | Transcriptional Role | Pathway | Comment | KEGG ID |
|---|---|---|---|---|
| 5'UTR mutated | ||||
| AP-1 | Activator[44] | Oestrogen signalling pathway | Pro-cancerous | map05224 |
| MAPK signalling | map05418 | |||
| IL17 signalling pathway | map04657 | |||
| CACCC binding factor/KLF3 | Repressor[45] | Transcriptional misregulation | Tumour suppressor | map05202 |
| c-Fos | Activator[46]. | MAPK signalling | Pro-cancerous | map04010 |
| Prolactin signalling pathway | map04917 | |||
| c-Jun | Activator[47] | FasL pathway | Pro-apoptotic | map04210 |
| c-Myc | Activator[48] | MAPK signalling | Pro-cancerous | map05200 |
| CPE_binding_pro/CREB1 | Activator[49] | Canonical wnt pathway | Pro-cancerous | map05225 |
| c-GMP-PKG pathway | map04022 | |||
| E2F | Activator[50] | Cell cycle | Tumour suppressor | map05200 |
| Cell senescence | map04218 | |||
| MyoD | Repressor[51] | Myogenesis | Tumour suppressor | map05017 |
| P1/foxp1 | Repressor[52] | Oestrogen signalling | Tumour suppressive | map05206 |
| 3'UTR | ||||
| Sp1 | Activator[53] | Choline metabolism | Pro-cancerous | map05231 |
| NF-kappaB1/p50 | Activator[54] | NFKB signalling | Pro survival | map04064 |
| NF-kappaB | Activator[55] | IL-17 signalling pathway | Pro-inflammatory | map04657 |
| TLR2 signalling | Pro-inflammatory | map05321 | ||
| ICSBP/irf8 | Activator[56] | PagP signalling | PRO-INFLAMMATORY | map05133 |
| TBP | Activator[57] | Gene expression | Pro-cancerous | map05203 |