. Author manuscript; available in PMC: 2022 Oct 31.

Published in final edited form as: Pediatr Allergy Immunol. 2022 Mar;33(3):e13753. doi: 10.1111/pai.13753

TABLE 5.

Results of hypothesis tests in unadjusted and adjusted CPH models comparing rate of offspring development of allergic diseases between the three-child filaggrin (FLG) mutation and maternal diet index groups

	Unadjusted (N = 624)			Adjusted^† (N = 492)
	Groups^‡ compared			Groups^‡ compared
	Group 1^c vs. Group 2^d (ref^§)	Group 1 vs. Group 3^e (ref^§)	Group 2 vs. Group 3 (ref^§)	Group 1 vs. Group 2 (ref^§)	Group 1 vs. Group 3 (ref^§)	Group 2 vs. Group 3 (ref^§)
Allergic disease	Hazard Ratio (95% CI^¶)			Hazard Ratio (95% CI^¶)
Allergic rhinitis	1.36 (0.71, 2.62)	3.20 (1.55, 6.61)^**	2.35 (1.42, 3.87)^***	2.29 (1.10, 4.76)^*	3.21 (1.46, 7.08)^**	1.40 (0.76, 2.57)
Atopic dermatitis	0.95 (0.57, 1.56)	2.45 (1.42, 4.21)^**	2.59 (1.84, 3.64)^***	1.30 (0.74, 2.29)	2.40 (1.32, 4.37)^**	1.85 (1.23, 2.78)^**
Asthma	0.99 (0.53, 1.88)	2.36 (1.18, 4.71)^*	2.37 (1.54, 3.65)^***	1.27 (0.61, 2.63)	2.29 (1.05, 4.97)^*	1.80 (1.07, 3.02)^*
Wheeze	0.96 (0.52, 1.77)	2.19 (1.14, 4.24)^*	2.28 (1.52, 3.41)^***	1.29 (0.65, 2.58)	2.10 (1.004, 4.38)^*	1.62 (0.995, 2.64)

^†

Adjusted for the following covariates: gestational smoking, nulliparity, maternal history of asthma, mode of delivery, breastfeeding duration, age of introduction of solid foods, child’s race/ethnicity, and child’s sex.

^‡

Group 1: children with FLG mutation; Group 2: children without FLG mutation whose mothers did not eat an allergy preventive diet; Group 3: children without FLG mutation whose mothers ate an allergy preventive diet.

^§

The reference group is indicated with the abbreviation “ref”.

^¶

CI: confidence interval.

p < 0.05

^**

p < 0.01

^***

p < 0.001