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. 2022 Nov 1;132(21):e151363. doi: 10.1172/JCI151363

Figure 7. Gland cells express YAP, which upon infection with H. pylori, is translocated to the nucleus.

Figure 7

(A and B) GSEA of microarray data comparing the expression profile of the corpus tissue from (A) 2-month–infected Rspo3-KI mice and infected littermate controls treated with tamoxifen 2 months before euthanasia, (B) 2-month–infected Rspo3-KO mice and infected littermate controls treated with tamoxifen 2 months before euthanasia with a published data set for repairing epithelium signature (22). (C and D) Representative immunofluorescence images of costaining for YAP (red) and E-cadherin (green) of sections from (C) noninfected and (D) infected Rspo3-KI and Rspo3-WT mice. Arrows show cytoplasmatic YAP. (E–G) Representative immunofluorescence images of nonphosphorylated (=active nuclear) YAP (red) of sections from (E) noninfected, (F) infected Rspo3-WT, and Rspo3-KI mice, and (G) infected Rspo3-KO mice. (H) Percentage of epithelial YAP+ nuclei (costained with E-cadherin) in the gland bases of sections from noninfected and 2-month–infected Rspo3-KI, Rspo3-KO, and Rspo3-WT mice. For GSEA, n = 2 mice per group. Scale bars: 50 μm. One-way ANOVA with Tukey’s multiple-comparison test.